Applications and side effects of common chemotherapy drugs for breast cancer - USWebPros Articles_2433

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Applications and side effects of common chemotherapy drugs for breast cancer - USWebPros Articles

Chemotherapy drugs in treatment of breast cancer are generally interfering the reproduction of cancer cells by changing or inhibiting the biochemical metabolic processes of cancer cells.Chemotherapy drugs in treatment of breast cancer are generally interfering the reproduction of cancer cells by changing or inhibiting the biochemical metabolic processes of cancer cells. According to cell cycle phase, they can be divided into two categories: cell cycle specific drugs and cell cycle non-specific drugs.Cell cycle specific drugs only have a role in cell cycle-specific, such as antimetabolites and mitotic inhibitors. Cell cycle-specific drugs, the moment of any of these drugs in the cell cycle phase has an effect on non-proliferation of cell cycle also played a role, such as alkylating agents and antibiotics. Some tumors at the beginning of chemotherapy, further treatment resistance; or when chemotherapy will be a large number of sensitive cancer cells eradication of drug resistance of tumor cells has become a major cell population. Therefore, in the promotion of combination chemotherapy, high-dose intermittent medication, chemotherapy,Obtenez le meilleur concepteur et de marque magasi, in order to reduce the occurrence of failure of chemotherapy or delay resistance occurrence.Common pharmaceutical raw materials for breast cancer include alkylating agents,Nike Air Force One, antimetabolite, antibiotics, alkaloids and taxanes. Alkylating agents can interfere with and destroy cancer cells nucleic acid and protein synthesis, mainly destruction of DNA replication. It is non-specific drugs, cell cycle and cell killing effect of the proliferation cycle of any one, and non-proliferation cycle, it has a broad-spectrum anti-tumor effect, and the killing effect of alkylating agents on cancer cells, rapid destruction of death in cancer cells. But it is cancer and normal tissue has same killing effects on the metabolism of bone marrow, the stronger the toxic effects of the gastrointestinal mucosal epithelium.Antimetabolites inhibit the synthesis of DNA or RNA, thereby preventing cell growth and proliferation of cancer cells. Common drugs are fluorouracil and methotrexate. These drugs cause gastrointestinal side effects are loss of appetite, nausea, vomiting, stomatitis, gastritis, diarrhea,Small Yet Perfect Data Storage Solution AIT3 tapes, severe bloody diarrhea. The white blood cell and platelet decline, severe cases can have whole blood decreased. The injection site can cause phlebitis. Arterial infusion may cause local skin erythema, edema, ulceration, pigmentation. A few may have cerebellar degeneration and ataxia. It may cause hair loss, dermatitis and black nail bed.Antibiotics for the cell cycle non-specific drugs, antibiotics used to treat breast cancer with mitomycin C and doxorubicin. Side effects of bone marrow suppression and oral ulcers. Produce cardiac toxicity, vomiting, nausea and diarrhea may also occur. Liver and kidney dysfunction, and return to normal growth of hair after the hair loss is a common phenomenon, but withdrawal. Alkaloids in cell cycle specific drugs, can inhibit cell mitosis, allows cancer cells to stop mitotic cells. Alkaloids for the treatment of breast cancer drugs vincristine, vinblastine, and colchicine. Nervous system toxicity than more medication for three weeks, and some patients have movement disorders, bone marrow suppression and gastrointestinal tract was mild, and also local stimulation, such as liquid leakage can cause local tissue necrosis. In addition to the peripheral nervous system disorders and can still plant nerve involvement, constipation, abdominal pain often occurs, enema and laxative treatment.Docetaxel can only be used for intravenous infusion. All patients must receive oral glucocorticoids such as dexamethasone before docetaxel treatment. In addition to pretreatment, if there are only mild symptoms such as facial flushing, skin reactions, a slightly faster heart rate, slightly lower blood pressure, the medicine can not be discontinued. Although docetaxel cost is reasonable and its performances are excellent, the drip rate should be slow down at that time. But if the serious reactions such as blood pressure, angioneurotic edema, respiratory difficulties and body hives happen, the docetaxel treatment should be discontinued and the patients need appropriate treatment. Severe allergic patients should not use docetaxel treatment next time.Source:http://www.cospcn.com